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A role for noncoding variation in schizophrenia
Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Plenge RM, Raychaudhuri S, Fromer M, Purcell SM, Bren
Cell Rep 2014 Nov 20;9(4):1417-29 doi: 10.1016/j.celrep.2014.10.015
PMID: 25453756
PMCID: PMC4255904
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Pharmacogenetics of the G protein-coupled receptors
Thompson MD, Cole DE, Capra V, Siminovitch KA, Rovati GE, Burnham WM, Rana BK.
Methods Mol Biol 2014;1175:189-242 doi: 10.1007/978-1-4939-0956-8_9
PMID: 25150871
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Serum 14-3-3? is a novel marker that complements current serological measurements to enhance detection of patients with rheumatoid arthritis
Maksymowych WP, Naides SJ, Bykerk V, Siminovitch KA, van Schaardenburg D, Boers M, LandewÚ R, van der Heijde D, Tak PP, Genovese MC, Weinblatt ME, Keystone EC, Zhukov OS, Abolhosn RW, Popov JM, Britsemmer K, van Kuijk AW, Marotta A.
J Rheumatol 2014 Nov;41(11):2104-13 doi: 10.3899/jrheum.131446
PMID: 25128504
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Genotype-positive status in patients with hypertrophic cardiomyopathy is associated with higher rates of heart failure events
Li Q, Gruner C, Chan RH, Care M, Siminovitch K, Williams L, Woo A, Rakowski H.
Circ Cardiovasc Genet 2014 Aug;7(4):416-22 doi: 10.1161/CIRCGENETICS.113.000331
PMID: 24909666
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Significance of left ventricular apical-basal muscle bundle identified by cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy
Gruner C, Chan RH, Crean A, Rakowski H, Rowin EJ, Care M, Deva D, Williams L, Appelbaum E, Gibson CM, Lesser JR, Haas TS, Udelson JE, Manning WJ, Siminovitch K, Ralph-Edwards AC, Rastegar H, Maron BJ, Maron MS.
Eur Heart J 2014 Oct 14;35(39):2706-13 doi: 10.1093/eurheartj/ehu154
PMID: 24810389
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Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPAR?
Xu E, Forest MP, Schwab M, Avramoglu RK, St-Amand E, Caron AZ, Bellmann K, Shum M, Voisin G, Paquet M, Montoudis A, LÚvy E, Siminovitch KA, Neel BG, Beauchemin N, Marette A.
Hepatology 2014 May;59(5):1803-15 doi: 10.1002/hep.26957
PMID: 24327268
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Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis
Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M.
Nat Commun 2011;2:334 doi: 10.1038/ncomms1333
PMID: 21629267
PMCID: PMC3133923
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Compartmentalized CDK2 is connected with SHP-1 and ▀-catenin and regulates insulin internalization
Fiset A, Xu E, Bergeron S, Marette A, Pelletier G, Siminovitch KA, Olivier M, Beauchemin N, Faure RL.
Cell Signal 2011 May;23(5):911-9 doi: 10.1016/j.cellsig.2011.01.019
PMID: 21262353
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Navigating the road to personalized medicine: can we believe
Hirschfield GM, Amos CI, Siminovitch KA.
CMAJ 2010 Apr 20;182(7):651-2 doi: 10.1503/cmaj.100300
PMID: 20371645
PMCID: PMC2855909
Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells.
Hadjiyanni I, Siminovitch KA, Danska JS, Drucker DJ.
Diabetologia 2010 Apr;53(4):730-40
PMID: 20225396
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Toward the molecular dissection of primary biliary cirrhosis
Hirschfield GM, Siminovitch KA.
Hepatology 2009 Nov;50(5):1347-50 doi: 10.1002/hep.23252
PMID: 19876938
Multiparameter phospho-flow analysis of lymphocytes in early rheumatoid arthritis: implications for diagnosis and monitoring drug therapy
Galligan CL, Siebert JC, Siminovitch KA, Keystone EC, Bykerk V, Perez OD, Fish EN.
PLoS One 2009 Aug 20;4(8):e6703 doi: 10.1371/journal.pone.0006703
PMID: 19693272
PMCID: PMC2724743
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Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling
Wang Q, Rajshankar D, Branch DR, Siminovitch KA, Herrera Abreu MT, Downey GP, McCulloch CA.
J Biol Chem 2009 Jul 31;284(31):20763-72 doi: 10.1074/jbc.M808828200
PMID: 19497848
PMCID: PMC2742840
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Metagenomics and autoimmune liver disease: searching for the unknown
Hirschfield GM, Siminovitch KA.
Liver Int 2009 Mar;29(3):319-20 doi: 10.1111/j.1478-3231.2009.01974.x
PMID: 19267861
Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils
Shi Y, Dong B, Miliotis H, Liu J, Alberts AS, Zhang J, Siminovitch KA.
Biochem Cell Biol 2009 Feb;87(1):207-16 doi: 10.1139/O08-130
PMID: 19234535
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Utility of incorporating genetic variants for the early detection of prostate cancer
Nam RK, Zhang WW, Trachtenberg J, Seth A, Klotz LH, Stanimirovic A, Punnen S, Venkateswaran V, Toi A, Loblaw DA, Sugar L, Siminovitch KA, Narod SA.
Clin Cancer Res 2009 Mar 1;15(5):1787-93 doi: 10.1158/1078-0432.CCR-08-1593
PMID: 19223501
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Primer: genomic and proteomic tools for the molecular dissection of disease
Walker EJ, Siminovitch KA.
Nat Clin Pract Rheumatol 2007 Oct;3(10):580-9
PMID: 17906613
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A genome-wide association screen identifies regions on chromosomes 1q25 and 7p21 as risk loci for sporadic prostate cancer
Nam RK, Zhang WW, Loblaw DA, Klotz LH, Trachtenberg J, Jewett MA, Stanimirovic A, Davies TO, Toi A, Venkateswaran V, Sugar L, Siminovitch KA, Narod SA.
Prostate Cancer Prostatic Dis 2008;11(3):241-6
PMID: 17876339
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T cell responses in mammalian diaphanous-related formin mDia1 knock-out mice
Eisenmann KM, West RA, Hildebrand D, Kitchen SM, Peng J, Sigler R, Zhang J, Siminovitch KA, Alberts AS.
J Biol Chem 2007 Aug 24;282(34):25152-8
PMID: 17595162
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A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate
Thompson MD, Capra V, Takasaki J, Maresca G, Rovati GE, Slutsky AS, Lilly C, Zamel N, McIntyre Burnham W, Cole DE, Siminovitch KA.
Pharmacogenet Genomics 2007 Jul;17(7):539-49
PMID: 17558309
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