||Technician IV/Research Associate
||Lunenfeld-Tanenbaum Research Institute
||Temporary Full Time (1 year)
|HOURS OF WORK
||37.5 hours per week
ORGANIZATION OR DEPARTMENT DESCRIPTION:
The Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, a University of Toronto affiliated research centre, is one of the world's leading centres in biomedical research. With ground-breaking discoveries in research areas such as diabetes, genetic disorders, cancer and women’s and infants’ health, the Institute is committed to excellence in health research and the training of young investigators. Strong partnerships with the clinical programs of Mount Sinai Hospital ensure that scientific knowledge is used to promote human health. Your significant contributions will assist in maintaining our momentum in advancing our research. . The Gingras laboratory is a world-class functional proteomics laboratory that develops experimental and computational tools to analyze protein-protein interactions in space and time. Recently-funded research investigates the role of signaling molecules in diseases, including cancers. More information about our group can be found at: gingraslab.lunenfeld.ca.
A temporary full time position (1 year contract) is available for a Research Associate to study the Hippo signalling pathway in colorectal cancer using proteomics approaches. The successful applicant will use a variety of proteomic technologies to analyze protein-protein interactions and phosphorylation. We have a well-established proteomics facility (proteomics.lunenfeld.ca) with a range of state-of-the-art mass spectrometers, all equipped with modern nanoflow liquid chromatography and customized bioinformatic support for qualitative and quantitative biological mass spectrometry.
The successful candidate will work as part of a team of cancer experts, structural biologists and biochemists to advance the understanding of deregulation of the Hippo signaling pathway in colorectal cancers. The research associate will express, in primary cells and colorectal cancer cells, components of the Hippo signaling pathway, recover these proteins by affinity enrichment and identify them by mass spectrometry. The Research Associate will also develop quantitative proteomics approaches to detect changes in phosphorylation for members of this signaling pathway. The Research Associate will work closely with members of the Gingras group and collaborators to accelerate research and discovery. S/he will plan experiments, analyze data, evaluate results, present regular progress updates in oral and written form and help in drafting progress reports and scientific manuscripts.
EDUCATION & EXPERIENCE REQUIREMENTS:
- Ph.D. with 2 years experience (or M. Sc. with 6 years experience) in mammalian signal transduction, cancer biology, proteomics sample preparation or any combination of equivalent experience and training.
- Demonstrated proficiency in some or all of the following techniques: molecular biology, mammalian tissue culture (including primary cell culture, lentiviral-mediated gene delivery and microscopy), biochemistry (including protein purification and enzymatic assays), biological mass spectrometry, peptide quantification, bioinformatics.
- Must be able to exercise good judgment, exercise considerable independence and take initiative
- Demonstrated analytical and problem solving abilities with strong attention to detail
- Must possess exceptional communication skills (verbal, written and presentation) and be comfortable engaging and exchanging information with other members of the laboratory and collaborators.
- Must demonstrate satisfactory work performance and attendance record
Posting open until April 10, 2017. We thank all candidates for applying. Only those selected for an interview will be contacted.
In accordance with Institute’s policy and legislated health and safety requirements, employment is conditional upon the verification of credentials, completion of a health review, and demonstrating proof of immunity and vaccination status of vaccine-preventable diseases.
The Lunenfeld-Tanenbaum Research Institute is a scent sensitive environment and all members of the community are expected to refrain from wearing or using scented products while visiting or working at the Institute. We also support a barrier-free workplace supported by the Institute’s accessibility plan, accommodation and disability management policies and procedures. Should you require accommodation at any point during the recruitment process, including accessible job postings, please contact the Lunenfeld-Tanenbaum Human Resources Department.