Woodgett, James

Inhibition of GSK3ß-mediated BACE1 expression reduces Alzheimer-associated phenotypes
Ly PT, Wu Y, Zou H, Wang R, Zhou W, Kinoshita A, Zhang M, Yang Y, Cai F, Woodgett J, Song W
Journal of Clinical Investigation 1/2/2013
► Abstract »
► J Clin Invest. 2013 Jan 2;123(1):224-35. »
► DOI: 10.1172/JCI64516 »

GSK3ß mediates muscle pathology in myotonic dystrophy
Jones K, Wei C, Iakova P, Bugiardini E, Schneider-Gold C, Meola G, Woodgett J, Killian J, Timchenko NA, Timchenko LT
Journal of Clinical Investigation 12/3/2012
► Abstract »
► J Clin Invest. 2012 Dec 3;122(12):4461-72. »
► DOI: 10.1172/JCI64081 »

Inactivation of the Enzyme GSK3a by the Kinase IKKi Promotes AKT-mTOR Signaling Pathway that Mediates Interleukin-1-Induced Th17 Cell Maintenance
Gulen MF, Bulek K, Xiao H, Yu M, Gao J, Sun L, Beurel E, Kaidanovich-Beilin O, Fox PL, Dicorleto PE, Wang JA, Qin J, Wald DN, Woodgett JR, Jope RS, Carman J, Dongre A, Li X
Immunity 11/16/2012
► Abstract »
► Immunity. 2012 Nov 16;37(5):800-12. »
► DOI: 10.1016/j.immuni.2012.08.019 »

Specific deletion of glycogen synthase kinase-3ß in the renal proximal tubule protects against acute nephrotoxic injury in mice
Howard C, Tao S, Yang HC, Fogo AB, Woodgett JR, Harris RC, Rao R
Kidney International 11/1/2012
► Abstract »
► Kidney Int. 2012 Nov;82(9):1000-9. »
► DOI: 10.1038/ki.2012.239 »

GSK-3a and GSK-3ß Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation
Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algül H, Schmid RM, Chung UI, Kawaguchi H
Journal of Biological Chemistry 8/24/2012
► Abstract »
► J Biol Chem. 2012 Aug 24;287(35):29227-36. »
► DOI: 10.1074/jbc.M112.372086 »

The effects of glycogen synthase kinase-3beta in serotonin neurons
Zhou W, Chen L, Paul J, Yang S, Li F, Sampson K, Woodgett JR, Beaulieu JM, Gamble KL, Li X
PLoS ONE 8/17/2012
► Abstract »
► PLoS One. 2012;7(8):e43262. »
► DOI: 10.1371/journal.pone.0043262 »

Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation
Hicks JW, Wilson AA, Rubie EA, Woodgett JR, Houle S, Vasdev N
Bioorganic & Medicinal Chemistry Letters 3/1/2012
► Abstract »
► Bioorg Med Chem Lett. 2012 Mar 1;22(5):2099-101. »
► DOI: 10.1016/j.bmcl.2011.12.139 »

Glycogen synthase kinase-3a limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death
Lal H, Zhou J, Ahmad F, Zaka R, Vagnozzi RJ, Decaul M, Woodgett J, Gao E, Force T
Circulation 1/3/2012
► Abstract »
► Circulation. 2012 Jan 3;125(1):65-75. »
► DOI: 10.1161/CIRCULATIONAHA.111.050666 »

Targeting GSK-3 family members in the heart: A very sharp double-edged sword
Cheng H, Woodgett J, Maamari M, Force T
Journal of Molecular and Cellular Cardiology 10/1/2011
► Abstract »
► J Mol Cell Cardiol. 2011 Oct;51(4):607-13. »
► DOI: 10.1016/j.yjmcc.2010.11.020 »

Genetic inactivation of GSK3a rescues spine deficits in Disc1-L100P mutant mice
Lee FH, Kaidanovich-Beilin O, Roder JC, Woodgett JR, Wong AH
Schizophrenia Research 6/1/2011
► Abstract »
► Schizophr Res. 2011 Jun;129(1):74-9. »
► DOI: 10.1016/j.schres.2011.03.032 »

Deletion of Glycogen Synthase Kinase-3{beta} in Cartilage Results in Up-Regulation of Glycogen Synthase Kinase-3{alpha} Protein Expression
Gillespie JR, Ulici V, Dupuis H, Higgs A, Dimattia A, Patel S, Woodgett JR, Beier F
Endocrinology 5/1/2011
► Abstract »
► Endocrinology. 2011 May;152(5):1755-66. »
► DOI: 10.1210/en.2010-1412 »

Selective loss of glycogen synthase kinase-3a in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation
Alon LT, Pietrokovski S, Barkan S, Avrahami L, Kaidanovich-Beilin O, Woodgett JR, Barnea A, Eldar-Finkelman H
FEBS Letters 4/20/2011
► Abstract »
► FEBS Lett. 2011 Apr 20;585(8):1158-62. »
► DOI: 10.1016/j.febslet.2011.03.025 »

Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.
Lipina TV, Kaidanovich-Beilin O, Patel S, Wang M, Clapcote SJ, Liu F, Woodgett JR, Roder JC
Synapse 3/1/2011
► Abstract »
► Synapse. 2011 Mar;65(3):234-48. »
► DOI: 10.1002/syn.20839 »

ß-Catenin activation synergizes with PTEN loss to cause bladder cancer formation
Ahmad I, Morton JP, Singh LB, Radulescu SM, Ridgway RA, Patel S, Woodgett J, Winton DJ, Taketo MM, Wu XR, Leung HY, Sansom OJ
Oncogene 1/13/2011
► Abstract »
► Oncogene. 2011 Jan 13;30(2):178-89. »
► DOI: 10.1038/onc.2010.399 »

Tissue-specific analysis of glycogen synthase kinase-3a (GSK-3a) in glucose metabolism: effect of strain variation
Patel S, Macaulay K, Woodgett JR
PLoS ONE 1/6/2011
► Abstract »
► PLoS One. 2011 Jan 6;6(1):e15845. »
► DOI: 10.1371/journal.pone.0015845 »

Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival
Song B, Lai B, Zheng Z, Zhang Y, Luo J, Wang C, Chen Y, Woodgett JR, Li M
Journal of Biological Chemistry 12/24/2010
► Abstract »
► J Biol Chem. 2010 Dec 24;285(52):41122-34. »
► DOI: 10.1074/jbc.M110.130351 »

Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol
Radulescu S, Ridgway RA, Appleton P, Kroboth K, Patel S, Woodgett J, Taylor S, Nathke IS, Sansom OJ.
Oncogene 12/9/2010
► Abstract »
► Oncogene. 2010 Dec 9;29(49):6418-27. »
► DOI: 10.1038/onc.2010.373 »

Conditional ablation of Gsk-3ß in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice
Liu Y, Tanabe K, Baronnier D, Patel S, Woodgett J, Cras-Méneur C, Permutt MA
Diabetologia 12/1/2010
► Abstract »
► Diabetologia. 2010 Dec;53(12):2600-10. »
► DOI: 10.1007/s00125-010-1882-x »

Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility
Liang W, Oudit GY, Patel MM, Shah AM, Woodgett JR, Tsushima RG, Ward ME, Backx PH
Hypertension 9/1/2010
► Abstract »
► Hypertension. 2010 Sep;56(3):422-9. »
► DOI: 10.1161/HYPERTENSIONAHA.109.149344 »

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice
Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T
Journal of Clinical Investigation 7/1/2010
► Abstract »
► J Clin Invest. 2010 Jul 1;120(7):2280-91. »
► DOI:10.1172/JCI41407 »

When pathways collide: collaboration and connivance among signalling proteins in development
McNeill H, Woodgett JR
Nature Reviews Molecular Cell Biology 6/1/2010
► Abstract »
► Nat Rev Mol Cell Biol. 2010 Jun;11(6):404-13. »
► DOI:10.1038/nrm2902 »

Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo
Woulfe KC, Gao E, Lal H, Harris D, Fan Q, Vagnozzi R, DeCaul M, Shang X, Patel S, Woodgett JR, Force T, Zhou J
Circulation Research 5/28/2010
► Abstract »
► Circ Res. 2010 May 28;106(10):1635-45. »
► DOI:10.1161/CIRCRESAHA.109.211482 »

GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity
Rao R, Patel S, Hao C, Woodgett J, Harris R
Journal of the American Society of Nephrology 3/1/2010
► Abstract »
► J Am Soc Nephrol. 2010 Mar;21(3):428-37. »
► DOI:10.1681/ASN.2009060672 »

GSK-3 is a master regulator of neural progenitor homeostasis
Kim WY, Wang X, Wu Y, Doble BW, Patel S, Woodgett JR, Snider WD
Nature Neuroscience 11/1/2009
► Abstract »
► Nat Neurosci. 2009 Nov;12(11):1390-7. Epub 2009 Oct 4 »
► DOI: 10.1038/nn.2408 »

Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression
Dillon RL, Marcotte R, Hennessy BT, Woodgett JR, Mills GB, Muller WJ
Cancer Research 6/15/2009
► Abstract »
► Cancer Res. 2009 Jun 15;69(12):5057-64. Epub 2009 Jun 2 »
► DOI: 10.1158/0008-5472.CAN-08-4287 »

Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development
Force T, Woodgett JR
Journal of Biological Chemistry 4/10/2009
► Abstract »
► J Biol Chem. 2009 Apr 10;284(15):9643-7. »
► DOI:10.1074/jbc.R800077200 »

Deletion of GSK-3 beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation
Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS
Journal of Clinical Investigation 11/1/2008
► Abstract »
► J Clin Invest. 2008 Nov;118(11):3609-18. Epub 2008 Oct 1 »
► DOI: 10.1172/JCI36245 »

Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation
Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS
Journal of Clinical Investigation 11/1/2008
► J Clin Invest. 2008 Nov;118(11):3609-18. »
► DOI:10.1172/JCI36245 »

Tissue-specific role of glycogen synthase kinase 3 beta in glucose homeostasis and insulin action
Patel S, Doble BW, MacAulay K, Sinclair EM, Drucker DJ, Woodgett JR
Molecular and Cellular Biology 10/1/2008
► Abstract »
► Mol Cell Biol. 2008 Oct;28(20):6314-28. Epub 2008 Aug 11 »
► DOI: 10.1128/MCB.00763-08 »

Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes
MacAulay K, Woodgett JR
Expert Opinion on Therapeutic Targets 10/1/2008
► Expert Opin Ther Targets. 2008 Oct;12(10):1265-74. »
► DOI: 10.1517/14728222.12.10.1265 »

GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism
Kapoor M, Liu S, Shi-wen X, Huh K, McCann M, Denton CP, Woodgett JR, Abraham DJ, Leask A
Journal of Clinical Investigation 10/1/2008
► J Clin Invest. 2008 Oct;118(10):3279-90. »
► DOI:10.1172/JCI35381 »

Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action
Patel S, Doble BW, MacAulay K, Sinclair EM, Drucker DJ, Woodgett JR
Molecular and Cellular Biology 10/1/2008
► Mol Cell Biol. 2008 Oct;28(20):6314-28. »
► DOI:10.1128/MCB.00763-08 »

GSK-3 beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism (Retracted article. See vol. 118, pg. 3812, 2008)
Kapoor M, Liu S, Shi-wen X, Huh K, McCann M, Denton CP, Woodgett JR, Abraham DJ, Leask A
Journal of Clinical Investigation 10/1/2008
► Abstract »
► J Clin Invest. 2008 Oct;118(10):3279-90 »
► DOI: 10.1172/JCI35381 »

Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action
Patel S, Doble BW, MacAulay K, Sinclair EM, Drucker DJ, Woodgett JR
Molecular and Cellular Biology 10/1/2008 »
► Mol Cell Biol. 2008 Oct;28(20):6314-28. »
► DOI:10.1128/MCB.00763-08 »

Targeting glycogen kinase-3 (GSK-3) in the treatment if Type 2 diabetes
MacAulay K, Woodgett JR
Expert Opinion on Therapeutic Targets 10/1/2008
► Abstract »
► Expert Opin Ther Targets. 2008 Oct;12(10):1265-74 »
► DOI: 10.1517/14728220802384161 »

Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung UI, Kawaguchi H
Journal of Clinical Investigation 7/1/2008
► J Clin Invest. 2008 Jul;118(7):2506-15. »
► DOI:10.1172/JCI35243 »

Phosphorylation of GSK-3 beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung UI, Kawaguchi H
Journal of Clinical Investigation 7/1/2008
► Abstract »
► J Clin Invest. 2008 Jul;118(7):2506-15 »
► DOI: 10.1172/JCI35243 »

The ground state of embryonic stem cell self-renewal
Ying QL, Wray J, Nichols J, Batlle-Morera L, Doble B, Woodgett J, Cohen P, Smith A
Nature 5/22/2008
► Nature. 2008 May 22;453(7194):519-23. »
► DOI:10.1038/nature06968 »

Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results
Bersudsky Y, Shaldubina A, Kozlovsky N, Woodgett JR, Agam G, Belmaker RH
Behavioural Pharmacology 5/1/2008
► Abstract »
► Behav Pharmacol. 2008 May;19(3):217-24. »
► DOI: 10.1097/FBP.0b013e3282feb099 »

Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide
Vasdev N, LaRonde FJ, Woodgett JR, Garcia A, Rubie EA, Meyer JH, Houle S, Wilson AA
Bioorganic & Medicinal Chemistry 5/1/2008
► Abstract »
► Bioorg Med Chem. 2008 May 1;16(9):5277-84. »
► DOI:10.1016/j.bmc.2008.03.013 »

Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts
Liu S, Fang X, Hall H, Yu S, Smith D, Lu Z, Fang D, Liu J, Stephens LC, Woodgett JR, Mills GB
Proceedings of the National Academy of Sciences of the United States of America 4/1/2008
► Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5248-53. »
► DOI:10.1073/pnas.0704242105 »

Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas
Salahshor S, Naidoo R, Serra S, Shih W, Tsao MS, Chetty R, Woodgett JR
Modern Pathology 3/1/2008
► Mod Pathol. 2008 Mar;21(3):271-81. »
► DOI:10.1038/modpathol.3800990 »

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance
Tanabe K, Liu Z, Patel S, Doble BW, Li L, Cras-Méneur C, Martinez SC, Welling CM, White MF, Bernal-Mizrachi E, Woodgett JR, Permutt MA
PLoS Biology 2/1/2008
► PLoS Biol. 2008 Feb;6(2):e37. »
► DOI:10.1371/journal.pbio.0060037 »

Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions
Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh JC, He X
Development 1/1/2008
► Development. 2008 Jan;135(2):367-75. »
► DOI:10.1242/dev.013540 »

Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines
Doble BW, Patel S, Wood GA, Kockeritz LK, Woodgett JR
Developmental Cell 6/1/2007
► Abstract »
► Dev Cell. 2007 Jun;12(6):957-71. »
► DOI:10.1016/j.devcel.2007.04.001 »

Differential gene expression profile reveals deregulation of pregnancy specific beta 1 glycoprotein 9 early during colorectal carcinogenesis
Salahshor S, Goncalves J, Chetty R, Gallinger S, Woodgett JR
BMC Cancer 6/27/2005
► Abstract »
► BMC Cancer. 2005 Jun 27;5:66 »
► DOI: 10.1186/1471-2407-5-66 »